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KMID : 1039620210110050372
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Korean Journal of Family Practice
2021 Volume.11 No. 5 p.372 ~ p.378
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Correlation between Gastroscopy Findings and Pepsinogen Values
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Yoon Da-In
Choi Moon-young
Yoon Yeo-Joon
Lee Hyun-Ki
Cho Sung-Jung
Kim Woo-Jeong
Kim Ji-Hoe
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Abstract
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Background: If the pepsinogen (PG) level could indicate the condition of the gastric mucosa, it can rapidly diagnose atrophic gastritis, a high risk factorfor stomach cancer. Based on varying distribution and location of secreted cells of PG I and PG II, this study aimed to determine the correlationbetween gastroscopy findings and PG levels.
Methods: From January to December 2018, gastroscopy findings in 103 subjects were compared according to PG I, PG II, and PG I/II ratio, withadjustments for sex, age, body mass index, underlying diseases, family history of stomach cancer, and social history.
Results: The group with atrophic gastritis had a significantly higher PG II value and a significantly lower PG I/II ratio than the control group. Those with ahigher Los Angeles classification of reflux esophagitis were observed to have higher PG I and II levels, although this finding was not statisticallysignificant. In cases of heartburn, duodenitis, intestinal metaplasia, and Helicobacter pylori infection, PG I and II levels were low, but not statisticallysignificant.
Conclusion: After adjusting for the characteristics of subjects, a low PG I/II ratio was found to be a useful predictive factor for atrophic gastritis.
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KEYWORD
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Pepsinogen, Atrophic Gastritis, Gastroscopy, Screening Test
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